These tumors make too much estrogen and androgen and can cause a mixed picture of signs and symptoms. In men, it can cause gynecomastia, infertility, and testicular and penile atrophy. gynecomastia), absence of pubic hair, and delayed growth of the penis. In boys, this can lead to developing breasts (i.e. These tumors make too much estrogen and cause a feminizing (i.e. hirsutism), acne, and ambiguous genitalia. In females, this can cause deepening of the voice, increased hair growth (i.e. These tumors make too much testosterone and can cause a virilizing (i.e. Sex-hormone producing tumors can produce either male hormones, female hormones, or both: Androgen secreting tumors metastases), or cancer that comes back (i.e. local invasion), spread to distant sites like the lung and bone (i.e. Although smaller tumors are more likely to benign, while larger tumors are more likely to be malignant, the only way to determine if a sex-hormone producing tumor is cancer is if there is spread into nearby organs (i.e. These tumors are found in 2 out of every million people and can be either benign (adenomas) or malignant (adrenocortical cancer). Sex-hormone producing adrenal tumors are rare tumors that make too much androgen (i.e.
